Epigenetic marks identify functional elements

Epigenetic marks identify functional elements

*
Randall H Morse

Journal name:
Nature Genetics
Volume:
42,
Pages:
282–284
Year published:
(2010)
DOI:
doi:10.1038/ng0410-282

Enhancers and transcription factor binding sites that control cell-specific transcription in higher eukaryotes can be found up to hundreds of kilobases from the promoters that they control, making their identification challenging. A new study uses a model based on histone modifications and chromatin dynamics to predict functional elements involved in androgen receptor response.