Perspectives
Nature Reviews Molecular Cell Biology 12, 259-265 (April 2011) | doi:10.1038/nrm3086
OPINION:The p53 family: guardians of maternal reproduction
Arnold J. Levine1, Richard Tomasini2, Frank D. McKeon3, Tak W. Mak4 & Gerry Melino5 About the authors
Abstract
The p53 family of proteins consists of p53, p63 and p73, which are transcription factors that affect both cancer and development. It is now emerging that these proteins also regulate maternal reproduction. Whereas p63 is important for maturation of the egg, p73 ensures normal mitosis in the developing blastocyst. p53 subsequently regulates implantation of the embryo through transcriptional control of leukaemia inhibitory factor. Elucidating the cell biological basis of how these factors regulate female fertility may lead to new approaches to the control of human maternal reproduction.
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